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refametinib-bay-86-9766

refametinib-bay-86-9766

Item no.	V0461-5mg
Manufacturer	InvivoChem LLC
CASRN	923032-37-5
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	923032-37-5
Available
Description	InvivoChem Cat #:V0461CAS #:923032-37-5Purity >=98% Description: Refametinib (formerly RDEA-119, BAY 86-9766) is an orally bioavailable, highly selective and non-ATP-competitive (allosteric) inhibitor of MEK1/2 with potential antitumor activity. It inhibits MEK1/2with IC50s of 19 nM and 47 nM, respectively. It exhibits excellent anti-proliferative activity in vitro against cancer cell lines harboring V600E BRAF mutant, with GI50 values ranging from 67nM to 89nM. Furthermore, Refametinib demonstrated high in vivo antitumor efficacy in the human melanoma A375 tumor xenograft model and caused obvious tumor growth regression. Description: References: Cancer Res. 2009 Sep 1; 69(17):6839-47; Int J Cancer. 2010 Dec 15; 127(12):2965-73. References: Related CAS: 923032-38-6 (Refametinib R enantiomer)
Molecular Weight (MW)	572.34
Formula	C19H20F3IN2O5S
CAS No.	923032-37-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
*Solubility (In vitro)*	DMSO: 100 mg/mL (174.7 mM)
	Water: < 1 mg/mL
	Ethanol: 100 mg/mL (174.7 mM)
Other info	IChemical Name: (S)-N-(3, 4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-6-methoxyphenyl)-1-(2, 3-dihydroxypropyl)cyclopropane-1-sulfonamide InChi Key: RDSACQWTXKSHJT-NSHDSACASA-N InChi Code: InChI=1S/C19H20F3IN2O5S/c1-30-15-7-13(21)16(22)18(24-14-3-2-10(23)6-12(14)20)17(15)25-31(28, 29)19(4-5-19)8-11(27)9-26/h2-3, 6-7, 11, 24-27H, 4-5, 8-9H2, 1H3/t11-/m0/s1 SMILES Code: O=S(C1(C[CH](O)CO)CC1)(NC2=C(OC)C=C(F)C(F)=C2NC3=CC=C(I)C=C3F)=O
Synonym	RDEA119, Bay 86-9766; RDEA119; RDEA 119; BAY 869766; BAY-69766; BAY869766; BAY 86 9766; BAY 86-9766; BAY869766; RDEA-119;

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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Delivery expected until 9/4/2025

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