SP600125 (SP600125; NSC75890)

Description: SP600125 (SP6-00125; NSC-75890) is a cell-permeable, broad-spectrum, reversible and ATP-competitive JNK (c-Jun N-terminal Kinase) inhibitor with potential anticancer and anti-inflammatory activity. It inhibits JNK1/2/3 with IC50s of 40 nM, 40 nM and 90 nM in cell-free assays, respectively. It shows potent anti-proliferative activity in vitro and high in vivo antitumor efficacy. SP600125 administration significantly inhibited TNF-alpha expression induced by LPS in a mouse model, suggesting that it had efficacy in endotoxin-induced inflammation in vivo.

References: Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13681-6; Cancer Res. 2010 Dec 15; 70(24):10255-64.

SP 600125; SP-600125; SP600125

Chemical Name: dibenzo[cd, g]indazol-6(2H)-one

InChi Key: ACPOUJIDANTYHO-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H, (H, 15, 16)

SMILES Code: O=C1C2=C3C(NN=C3C4=CC=CC=C14)=CC=C2