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sb239063

sb239063

Item no.	V0483-5mg
Manufacturer	InvivoChem LLC
CASRN	193551-21-2
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	193551-21-2
Available
Description	InvivoChem Cat #:V0483CAS #:193551-21-2Purity >=98% Description: SB239063 (SB-239063) is a novel, highly potent, orally bioactive and selective p38 MAPKalpha/beta inhibitor with potential anti-inflammatory activity. It inhibits p38 MAPKalpha/beta with an IC50 of 44 nM, and shows no/little activity against the p38 MAPK gamma- and delta-isoforms. SB 239063 displays > 220-fold selectivity for p38 MAPK over ERK, JNK1 and other kinases; and is around 3-fold more selective than SB 203580. In LPS (lipopolysaccharide)-stimulated human peripheral blood monocytes, SB 239063 inhibited interleukin-1 and tumor necrosis factor-alpha production (IC(50) values = 0.12 and 0.35 microM, respectively). SB 239063 may be useful for the treatment of asthma and other inflammatory disorders. Description: References: J Pharmacol Exp Ther. 2000 Apr; 293(1):281-8; Eur J Pharmacol. 2008 Sep 11; 592(1-3):55-61. References:
Molecular Weight (MW)	368.4
Formula	C20H21FN4O2
CAS No.	193551-21-2
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 60 mg/mL (162.9 mM)
	Water: < 1 mg/mL
	Ethanol: 7 mg/mL warmed (19.0 mM)
Other info	Chemical Name: (1r, 4r)-4-(4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)-1H-imidazol-1-yl)cyclohexanol InChi Key: ZQUSFAUAYSEREK-WKILWMFISA-N InChi Code: InChI=1S/C20H21FN4O2/c1-27-20-22-11-10-17(24-20)19-18(13-2-4-14(21)5-3-13)23-12-25(19)15-6-8-16(26)9-7-15/h2-5, 10-12, 15-16, 26H, 6-9H2, 1H3/t15-, 16- SMILES Code: O[CH]1CC[CH](N2C(C3=NC(OC)=NC=C3)=C(C4=CC=C(F)C=C4)N=C2)CC1
Synonyms	SB 239063; SB-239063; SB239063

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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