Comparison

Sunitinib free base (SU-11248)

Item no. V0497-500mg
Manufacturer InvivoChem LLC
CASRN 557795-19-4
Amount 500 mg
Quantity options 10 g 1 g 2 g 5 g
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias 557795-19-4
Available
Description
InvivoChem Cat #:V0497CAS #:557795-19-4 Purity >=98%

Description: Sunitinib (formerly also known as SU11248; trade name: Sutent) is a potent, orally bioavailable and multi-targeted RTK (receptor tyrosine kinase) inhibitor with potential antitumor activity. It inhibits VEGFR2 (Flk-1) and PDGFRbeta with IC50s of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib was approved by US FDA for the treatment of renal cell carcinoma andimatinib-resistant gastrointestinal stromal tumor in 2006. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation.

Description:

References: J Med Chem. 2003 Mar 27; 46(7):1116-9; Clin Cancer Res. 2003 Jan; 9(1):327-37; Blood. 2003 May 1; 101(9):3597-605.

References:

Related CAS: 1221149-36-5 (acetate); 42641-94-5; 1332306-95-2 (oxalate); 1126641-10-8 (maleate); 1275588-72-1 (mesylate); 341031-54-7 (malate); 557795-19-4 (free base); 1327155-72-5 (HCl)

Molecular Weight (MW)
398.47
Formula
C22H27FN4O2
CAS No.
557795-19-4(free);
Storage
-20C for 3 years in powder form
-80C for 2 years in solvent
Solubility (In vitro)
DMSO: 25 mg/mL (62.7 mM)
Water: < 1 mg/mL
Ethanol:< 1 mg/mL
Solubility (In vivo)
5% DMSO+corn oil: 7 mg/mL
Synonyms
SU11248; SU 11248; SU011248; SU-11248; sunitinib. trade name: Sutent.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 500 mg
Available: In stock
available

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question

Submit a bulk request

Questions about this Product?
 
Close