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Linifanib (ABT-869; AL-39324)

Linifanib (ABT-869; AL-39324)

Item no.	V0529-10mg
Manufacturer	InvivoChem LLC
CASRN	796967-16-3
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	796967-16-3
Available
Description	InvivoChem Cat #:V0529CAS #:796967-16-3Purity >=98% Description: Linifanib (formerly RG3635, ABT869, AL39324) is an orally bioavailable and ATP-competitive inhibitor of multiple kinases (e.g. VEGFR/PDGFR) with potential antitumor activity. It inhibits KDR, CSF-1R, Flt-1/3 and PDGFRbeta with IC50s of 4 nM, 3 nM, 3 nM/4 nM and 66 nM, respectively. Linifanib exhibits excellent anti-proliferative activity in vitro and high in vivo antitumor efficacy. Description: References: Mol Cancer Ther. 2006 Apr; 5(4):995-1006; Mol Cancer Ther. 2006 Apr; 5(4):1007-13; Mol Cancer Ther. 2011 Jun; 10(6):949-59. References:
Molecular Weight (MW)	375.41
Formula	C21H18FN5O
CAS No.	796967-16-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 75 mg/mL (199.8 mM)
	Water:< 1 mg/mL
	Ethanol:< 1 mg/mL
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% propylene glycol: 30 mg/mL
Synonyms	AL39324; ABT-869; RG3635; ABT869; AL 39324; RG-3635; ABT 869; RG 3635; AL-39324 Chemical Name: N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N1-(2-fluoro-5-methylphenyl) urea InChi Key: ACPCMBPQKQTAQY-UHFFFAOYSA-N InChi Code: InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)27(21(24)28)14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)26-25-17/h2-11H, 1H3, (H2, 24, 28)(H3, 23, 25, 26) SMILES Code: O=C(N)N(C1=CC=C(C2=CC=CC3=C2C(N)=NN3)C=C1)C4=CC(C)=CC=C4F

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Amount: 10 mg

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Delivery expected until 9/4/2025

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