gnf-2

Manufacturer	InvivoChem LLC
Category	Cell Biology Cell Stainings Reagents & Chemicals Cytosolic Tracers Molecules
Type	Biochemicals
Specific against	other
Amount	500mg
Item no.	V0678-500mg
CASRN	778270-11-4
eClass 6.1	32160405
eClass 9.0	32160490
Available
Description	InvivoChem Cat #:V0678CAS #:778270-11-4Purity >=98% Description: GNF-2 (GNF 2; GNF2) is a highly potent, selective and allosteric/non-ATP competitive inhibitor of Bcr-Abl with potential anticancer activity. It shows no activity against Flt3-ITD, Tel-PDGFR, TPR-MET and Tel-JAK1 transformed tumor cells. GNF-2 acts by allosterically binding the myristate-binding site of ABL and inhibits the proliferation of BCR-ABL positive cell and induces cell apoptosis. GNF-2 eliminatedtransplanted-CML-T315I-mutants in vivo and dose dependently sensitizedprimary cells from CML T315I patients to GNF-2-induced proliferationinhibition and apoptosis Description: GNF-2 eliminatedtransplanted-CML-T315I-mutants in vivo and dose dependently sensitizedprimary cells from CML T315I patients to GNF-2-induced proliferationinhibition and apoptosis References: Nat Chem Biol. 2006; 2(2):95-102; J Biol Chem. 2009; 284(42):29005-14; Nature. 2010; 463:501-6. References:
Molecular Weight (MW)	374.32
Formula	C18H13F3N4O2
CAS No.	778270-11-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 74 mg/mL (197.69 mM)
	Water:< 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: 3-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzamide InChi Key: WEVYNIUIFUYDGI-UHFFFAOYSA-N InChi Code: InChI=1S/C18H13F3N4O2/c19-18(20, 21)27-14-6-4-13(5-7-14)25-16-9-15(23-10-24-16)11-2-1-3-12(8-11)17(22)26/h1-10H, (H2, 22, 26)(H, 23, 24, 25) SMILES Code: O=C(N)C1=CC=CC(C2=NC=NC(NC3=CC=C(OC(F)(F)F)C=C3)=C2)=C1
Synonyms	GNF-2; GNF 2; GNF2;

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Amount: 500mg

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Delivery expected until 6/6/2024