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nirogacestat-pf-03084014-pf-3084014

nirogacestat-pf-03084014-pf-3084014

Item no.	V0723-5mg
Manufacturer	InvivoChem LLC
CASRN	1290543-63-3
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1290543-63-3
Available
Description	InvivoChem Cat #:V0723CAS #:1290543-63-3Purity >=98% Description: Nirogacestat (formerly also known as PF-03084014; PF03084014; PF 3084014; PF-3084014) is an orally bioavailable, reversible, noncompetitive, and selective gamma-secretase/gamma secretase (GS) inhibitor with potential anticancer activity. It inhibits gamma-secretase/gamma secretase with an IC50 value of 6.2 nM in a cell-free assay. Nirogacestat acts by binding to GS, blocking the proteolytic activation of Notch receptors. It was in a in Phase 3 clinical trial for patients with desmoid tumors. References: Mol Cancer Ther. 2010 Jun; 9(6):1618-28; Clin Cancer Res. 2012 Sep 15; 18(18):5008-19.
Molecular Weight (MW)	489.64
Formula	C27H41F2N5O
CAS No.	1290543-63-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 97 mg/mL (198.1 mM)
	Water: < 1 mg/mL
	Ethanol: 97 mg/mL (198.1 mM)
Other info	Chemical Name: (S)-2-(((S)-6, 8-difluoro-1, 2, 3, 4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide InChi Key: VFCRKLWBYMDAED-REWPJTCUSA-N InChi Code: InChI=1S/C27H41F2N5O/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5, 6)16-30-15-26(2, 3)4/h11-12, 14, 17, 20, 23, 30, 32H, 7-10, 13, 15-16H2, 1-6H3, (H, 33, 35)/t20-, 23-/m0/s1 SMILES Code: CCC[CH](N[CH]1CC2=C(C=C(F)C=C2F)CC1)C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)=O
Synonyms	PF 03084014; PF-3084014; Nirogacestat, PF03084014; PF-03084014; PF3084014; PF 3084014

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