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luminespib

luminespib

Item no.	V0873-5mg
Manufacturer	InvivoChem LLC
CASRN	747412-49-3
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	747412-49-3
Available
Description	InvivoChem Cat #:V0873CAS #:747412-49-3 Purity >=98% Description: Luminespib (also known as NVP AUY922; NVP AUY-922; AUY922; AUY-922; VER52296; VER-52296), a 4, 5-diarylisoxazole derivative, is a 3rd generation HSP90 (heat shock protein 90) inhibitor with potential anticancer activity. In inhibits HSP90alpha/beta with IC50s of 13 nM /21 nM in cell-free assays. Luminespib showed weaker potency against the HSP90 family members GRP94 and TRAP-1, and exhibits the tightest binding of any small-molecule HSP90 ligand. Structurally, luminespib is a derivative of 4, 5-diarylisoxazole and a third-generation heat shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. Description: References: Cancer Sci. 2011; 102(7):1388-95; Anticancer Res. 2011; 31(4):1197-204; Cancer Res. 2008; 68(8):2850-60. References: Related CAS: 747412-49-3 (free); 1051919-21-1 (Luminespib mesylate); 1051919-26-6 (Luminespib mesylate hydrate)
Molecular Weight (MW)	465.54
Formula	C26H31N3O5
CAS No.	747412-49-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 93 mg/mL (199.8 mM)
	Water: < 1 mg/mL
	Ethanol: 31 mg/mL (66.6 mM)
Solubility (In vivo)	1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL
Synonyms	Luminespib; NVP AUY922; AUY922; AUY-922; VER52296; VER-52296; NVP AUY-922; NVP-AUY922; NVP-AUY-922; AUY 922; VER 52296 Chemical Name: 5-(2, 4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide SMILES Code: O=C(C1=NOC(C2=CC(C(C)C)=C(O)C=C2O)=C1C3=CC=C(CN4CCOCC4)C=C3)NCC

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Delivery expected until 7/3/2025

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