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onalespib-at13387

onalespib-at13387

Item no.	V0878-25mg
Manufacturer	InvivoChem LLC
CASRN	912999-49-6
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V0878CAS #:912999-49-6 Purity >=98% Description: Onalespib (formerly AT13387; AT-13387; AT 13387) is a novel, orally bioavailable, long-acting and isoindole-based small-molecule HSP90 (heat shock protein 90) inhibitor with potential antitumor activity. It inhibits HSP90 with an IC50 of 18 nM in A375 cells, displays a long duration of anti-tumor activity. Onalespib is being studies in clinical trials for men with CRPC, in particular thos who have failed treatment with abiraterone acetate Description: References: Cancer Sci. 2012 Mar; 103(3):522-7. References: Related CAS: 1019889-35-0 (lactate); 912999-49-6 (free base);
Molecular Weight (MW)	409.52
Formula	C24H31N3O3
CAS No.	912999-49-6(free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 25 mg/mL (61.0 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	2% DMSO+30% PEG 300+ddH2O: 10 mg/mL
Synonyms	Onalespib lactate; AT13387; AT-13387; AT 13387; Onalespib; Chemical Name: (2, 4-dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone SMILES Code: O=C(C1=CC(C(C)C)=C(O)C=C1O)N2CC3=C(C=C(CN4CCN(C)CC4)C=C3)C2

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25mg

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Delivery expected until 7/3/2025

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