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jnj-1661010

jnj-1661010

Item no.	V0910-10mg
Manufacturer	InvivoChem LLC
CASRN	681136-29-8
Amount	10mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	681136-29-8
Available
Description	InvivoChem Cat #:V0910CAS #:681136-29-8Purity >=98% Description: JNJ-1661010 (JNJ 1661010; Takeda-25; JNJ1661010; Takeda25), a piperazinyl phenyl urea compound, is a selective and reversible inhibitor of Fatty acid amide hydrolase/FAAH with important biological activity. It inhibits FAAH with an IC50 of 10 nM (rat) and 12 nM (human), and exhibits > 100-fold selectivity for FAAH-1 over FAAH-2. JNJ-1661010 is structurally distinct from alkylcarbamic acid esters and alpha–ketoheterocyclic compounds. JNJ-1661010 is a brain penetrant and active in vivo, and thus has been used to examine the contribution of endocannabinoid signaling in experimental fibrosis. Description: References: Bioorg Med Chem Lett. 2008 Sep 1; 18(17):4838-43; Anesth Analg. 2009 Jan; 108(1):316-29. References:
Molecular Weight (MW)	365.45
Formula	C19H19N5OS
CAS No.	681136-29-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 36 mg/mL (98.5 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	5% DMSO+95% Corn oil: 5 mg/mL
Synonyms	Takeda 25; JNJ-1661010; Takeda-25; Takeda25; JNJ 1661010; JNJ1661010.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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