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Liproxstatin-1

Liproxstatin-1

Item no.	V0956-5mg
Manufacturer	InvivoChem LLC
CASRN	950455-15-9
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 2 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	950455-15-9
Available
Description	InvivoChem Cat #:V0956CAS #:950455-15-9Purity >=98% Description: Liproxstatin-1 (Lip-1) is a novel and potent inhibitor of ferroptosis with important biological activity. It inhibits ferroptosis with an IC50 value of 22 nM in cell free assays. Ferroptosis is a non-apoptotic form of cell death induced by small molecules in specific tumour types, and in engineered cells that overexpress oncogenic RAS. Liproxstatin-1 showed inhibition against ferroptosis-inducing agent (FIN) -triggered cell death. In Gpx4-/- cells, liproxstatin-1 inhibited RSL3-induced BODIPY 581/591 C11 oxidation. Description: References: Nat Cell Biol. 2014 Dec; 16(12):1180-91. References:
Molecular Weight (MW)	340.85
Formula	C19H21ClN4
CAS No.	950455-15-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 68 mg/mL (199.5 mM)
	Water: < 1 mg/mL
	Ethanol: 21 mg/mL (61.6 mM)
SMILES Code	ClC1=CC(CNC(C23CCNCC2)=NC4=C(N3)C=CC=C4)=CC=C1
Synonyms	Liproxstatin-1; Chemical Name: N-[(3-Chlorophenyl)methyl]-spiro[piperidine-4, 2?(1?H)-quinoxalin]-3?-amine

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Amount: 5 mg

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