Ziprasidone HCl (CP-88059)

Description: Ziprasidone (CP 88059; CP-88, 059; CP-88, 059-01; Geodon; Zeldox; Zipwell) HCl, the hydrochloride salt of Ziprasidone, is a novel and potent dopamine and serotonin (5-HT) receptor antagonist with antipsychotic effects. It has been approved for treating schizophrenia and bipolar disorder, schizophrenia, acute mania and mixed states associated with bipolar disorder. Its intramuscular injection form is approved for acute agitation in schizophrenic patients for whom treatment with just ziprasidone is appropriate. The mechanism of action of ziprasidone has been proposed that this drug's efficacy in schizophrenia is mediated through a combination of dopamine type 2 (D2) and serotonin type 2 (5HT2) antagonism. As with other drugs having efficacy in bipolar disorder, the mechanism of action of ziprasidone in bipolar disorder is unknown.

References: Biochem Pharmacol. 2006 Jan 12; 71(3):278-86; Eur J Pharmacol. 2004 Nov 28; 505(1-3):253-4.

Related CAS #: 122883-93-6 (HCl); 138982-67-9 (HCl hydrate); 199191-69-0 (Mesylate Trihydrate); 146939-27-7 (free base)