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AZ 628 (AZ-628; AZ628)

AZ 628 (AZ-628; AZ628)

Item no.	V1006-5mg
Manufacturer	InvivoChem LLC
CASRN	878739-06-1
Amount	5 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	878739-06-1
Available
Description	InvivoChem Cat #:V1006CAS #:878739-06-1Purity >=98% Description: AZ-628 (AZ628; AZ 628) is a novel, selective, and orally bioavailable Raf inhibitor with potential antineoplastic activity. It exhibits excellent pharmacokinetic properties and robust tumor growth inhibition in xenograft animal models. AZ-628 inhibits Raf isoforms such as c-Raf1, B-RafV600E and wild-type B-Raf with IC50 values of 29, 34 and 105 nM, respectively. AZ-628 potently inhibits the proliferation, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation. Description: References: Cancer Discov, 2013, 3(3):350-62. References:
Molecular Weight (MW)	451.52
Formula	C27H25N5O2
CAS No.	878739-06-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 90 mg/mL (199.3 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% propylene glycol: 30mg/mL

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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Delivery expected until 9/4/2025

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