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Description: Lorcaserin HCl (Belviq Xr; APD-356; APD356; Lorqess), the hydrochloride salt of Lorcaserin which is a marketed weight-loss drug, is a potent and selective full agonist of human 5-HT2C (serotonin) receptor with Ki of 15 nM. It reduces appetite by activating 5-HT2C receptor the hypothalamus, which is known to control appetite.
References: J Pharmacol Exp Ther. 2008 May; 325(2):577-87; J Pharmacol Exp Ther. 2011 Sep; 338(3):890-6.
Related CAS#: 616202-92-7 (free base); 856681-05-5 (HCl hydrate); 1361572-46-4 (Lorcaserin sulfamate)
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