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Prucalopride (R-108512, R-93877)

Prucalopride (R-108512, R-93877)

Item no.	V1036-25mg
Manufacturer	InvivoChem LLC
CASRN	179474-81-8
Amount	25 mg
Quantity options	100 mg 1 g 250 mg 500 mg 50 mg 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	179474-81-8
Available
Description	InvivoChem Cat #:V1036CAS #:179474-81-8 Purity >=98% Description: Prucalopride (Motegrity; R-108512; R 108512; Resolor; Resotran; R108512; Prudac), a novel enterokinetic compound and the first representative drug of the benzofuran class of laxatives, is a selective and high affinity 5-HT (serotonin) receptor agonist with Kis of 2.5 nM and 8 nM for 5-HT4A and 5-HT4B receptor, respectively. It exhibits > 290-fold selectivity against other 5-HT receptor subtypes. Prucalopride induces contractions in a concentration-dependent manner with pEC50 of 7.5. Prucalopride significantly amplifies the rebound contraction of the guinea-pig proximal colon after electrical field stimulation. Prucalopride was approved by FDA in December 2018 to treat chronic idiopathic constipation. Description: References: Eur J Pharmacol. 2001 Jun 29; 423(1):71-83; N Engl J Med. 2008 May 29; 358(22):2344-54. References: Related CAS#: 179474-85-2 (Succinate); 179474-80-7 (HCl)
Molecular Weight (MW)	367.87
Formula	C18H26ClN3O3
CAS No.	179474-81-8 (free base);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 60 mg/mL (163.1 mM)
	Water: < 1 mg/mL
	Ethanol: 38 mg/mL (103.3 mM)
Solubility (In vivo)	ClC1=C(N)C(CCO2)=C2C(C(NC3CCN(CCCOC)CC3)=O)=C1
Synonyms	R-93877; R 93877; R93877; trade names: Motegrity; Resolor; Resotran; R-108512; R 108512; R108512

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Amount: 25 mg

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Delivery expected until 9/4/2025

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