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indomethacin-indometacin

indomethacin-indometacin

Item no.	V1041-1g
Manufacturer	InvivoChem LLC
CASRN	53-86-1
Amount	1 g
Quantity options	100 g 10 g 25 g 2 g 50 g 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	53-86-1
Available
Description	InvivoChem Cat #:V1041CAS #:53-86-1Purity >=98% Description: Indomethacin (Indometacin; Indocin) is a potent and non-selective COX1 and COX2 inhibitor of the nonsteroidal anti-inflammatory drug (NSAID) class with an IC50 of 0.1 ug/mL and 5 ug/mL, respectively. Indomethacin is a synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties and is used to reduce fever, pain, stiffness, and swelling. Indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. Description: References: Oncogene. 2001 Feb 1; 20(5):645-53; Stroke. 2005 Dec; 36(12):2718-24; Inflammation. 1993 Dec; 17(6):641-62. References: Related CAS#: 2854-32-2 (BML-190; Indomethacin morpholinylamide; IMMA)
Molecular Weight (MW)	357.79
Formula	C19H16ClNO4
CAS No.	53-86-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 72 mg/mL (201.2 mM)
	Water: < 1 mg/mL
	Ethanol: 24 mg/mL (67.1 mM)
Other info	Chemical Name: 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid InChi Key: CGIGDMFJXJATDK-UHFFFAOYSA-N InChi Code: InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H, 10H2, 1-2H3, (H, 22, 23) SMILES Code: O=C(O)CC1=C(C)N(C(C2=CC=C(Cl)C=C2)=O)C3=C1C=C(OC)C=C3
Synonyms	Indometacin; Indocin.

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