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diclofenac-sodium-gp-45840

diclofenac-sodium-gp-45840

Item no.	V1051-5g
Manufacturer	InvivoChem LLC
CASRN	15307-79-6
Amount	5 g
Quantity options	100 g 10 g 200 g 25 g 50 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	15307-79-6
Available
Description	InvivoChem Cat #: V1051CAS #:15307-79-6Purity >=98% Description: Diclofenac Sodium (Abitren, Blesin, Delimon, Allvoran, Berifen, Delphimix, Voltaren, Voltarol; Assaren, Batafil, GP-45840) is a nonsteroidal anti-inflammatory drug (NSAID), acting as a non-selective COX inhibitor with potential anti-inflammatory activity. It inhibits COX-1/2 with IC50 of 0.5 ug/ml and 0.5 ug/ml in intact cells, respectively, and is used to relieve pain and reduce swelling in flammation. Diclofenac inhibits Wnt/beta-catenin signaling without altering the level of beta-catenin protein and reduces the expression of beta-catenin/TCF-dependent genes. Diclofenac induces the degradation of IkappaBalpha, which increases free nuclear factor kappaB (NF-kappaB) in colon cancer cells. Description: References: FEBS Lett. 2005 Aug 15; 579(20):4213-8; Biochim Biophys Acta. 1997 Feb 15; 1318(3):385-94. References: Related CAS #: 15307-86-5 (free base)
Molecular Weight (MW)	318.13
Formula	C14H10Cl2NNaO2
CAS No.	15307-79-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 64 mg/mL (201.2 mM)
	Water: 14 mg/mL (44.0 mM)
	Ethanol: 64 mg/mL (201.2 mM)
Other info	Chemical Name: Benzeneacetic acid, 2-((2, 6-dichlorophenyl)amino)-, monosodium salt InChi Key: KPHWPUGNDIVLNH-UHFFFAOYSA-M InChi Code: 1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19; /h1-7, 17H, 8H2, (H, 18, 19); /q; +1/p-1 SMILES: c1ccc(c(c1)CC(=O)[O-])Nc2c(cccc2Cl)Cl.[Na+]
Synonyms	GP-45840; Abitren, Voltaren, Voltaren-XR, Allvoran, Delimon, Neriodin, Orthophen, Sodium diclofenac, Voltarene, Voltarol; GP45840; GP 45840; Assaren, Batafil, Berifen, Delphimix, Diclofenac sodium, Blesin

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