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Description: Medetomidine HCl (MPV-785; MPV 785; MPV785; Precedex. Domitor; Selektope) is a selective and synthetic alpha2-adrenoceptor agonist with analgesic and anesthetic effects. It activates alpha2-adrenoceptor with a Ki of 1.08 nM, and exhibits 1620-fold selectivity over alpha1-adrenoceptor. Medetomidine has been approved for use as both a surgical anesthetic and analgesic. It is an alpha-2 adrenergic agonist that can be administered as an intravenous drug solution with sterile water. Medetomidine is a racemic mixture of two stereoisomers; dexmedetomidine is the isomer with more useful effects, and is now marketed as Dexdomitor.
References: Eur J Pharmacol. 1988 May 20; 150(1-2):9-14; J Auton Pharmacol. 1986 Dec; 6(4):275-84.
Related CAS #: 86347-15-1 (HCl) 86347-14-0 (free base)
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