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Description: Dexmedetomidine HCl (Precedex), the hydrochloride salt of Dexmedetomidine which is the dexter isomer of medetomidine, is a highly selective and potent alpha-2 adrenoceptor agonist with sedative effects. It reduces anesthetic requirements for patients by providing significant sedation. Dexmedetomidine has a relatively high ratio of alpha2/alpha1-activity (1620:1 as compared with 220:1 for clonidine) and, therefore, is considered a full agonist of the alpha2 receptor. This may result in more potent effects of sedation without unwanted cardiovascular effects from alpha1 receptor activation.
References: Eur J Pharmacol. 1988 May 20; 150(1-2):9-14; Anesthesiology. 1997 Feb; 86(2):331-45.
Related CAS #: 145108-58-3 (HCl) 113775-47-6 (free base)
Chemical Name: 5-[(1S)-1-(2, 3-Dimethylphenyl)ethyl]-1H-imidazole; hydrochloride
InChi Key: VPNGEIHDPSLNMU-MERQFXBCSA-N
InChi Code: InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13; /h4-8, 11H, 1-3H3, (H, 14, 15); 1H/t11-; /m0./s1
SMILES Code: C[CH](C1=CN=CN1)C2=CC=CC(C)=C2C.[H]Cl
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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