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Description: Trospium chloride (IP-631; IP 631; Sanctura; Trosec; Regurin; Flotros; Tropez OD; Spasmex; Spasmoly) is a potent and competitive muscarinic cholinergic receptor antagonist and a medication used to treat overactive bladder. It antagonizes the effect of acetylcholine on muscarinic receptors in cholinergically innervated organs including the bladder. Its parasympatholytic action reduces the tonus of smooth muscle in the bladder. Receptor assays showed that trospium chloride has negligible affinity for nicotinic receptors as compared to muscarinic receptors at concentrations obtained from therapeutic doses.
References: Int J Clin Pract. 2010 Oct; 64(11):1535-40; Ann Pharmacother. 2009 Feb; 43(2):283-95.
Related CAS#: 47608-32-2 (Trospium)
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