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darifenacin-hbr

darifenacin-hbr

Item no.	V1171-10mg
Manufacturer	InvivoChem LLC
CASRN	133099-07-7
Amount	10 mg
Quantity options	100 mg 1 g 250 mg 25 mg 2 g 500 mg 50 mg 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	133099-07-7
Available
Description	InvivoChem Cat #:V1171CAS #:133099-07-7Purity >=98% Description: Darifenacin HBr (formerly known as UK-88525; Emselex; Enablex), the hydrobromide salt of Darifenacin, is a approved medication used to treat urinary incontinence and overactive bladder. It acts as a selective M3 muscarinic receptor antagonist with pKi of 8.9. Darifenacin exerts non-parallel rightward displacement of the agonist curve and also significant depression of the maximum response (+)-cis-Dioxolane produced concentration-dependent contraction of the isolated bladder of rat. Darifenacin produces a concentration dependent increase in R123 (P-gp probe) accumulation in MDCK cells. Darifenacin stimulates ATPase activity in P-gp membrane in a clear concentration dependent response manner with an estimated ED50 value of 1.6?uM. Description: References: Br J Pharmacol. 1997 Apr; 120(8):1409-18; Neurourol Urodyn. 2011 Nov; 30(8):1633-8. References: Related CAS #: 133099-04-4 (free base) 133099-07-7 (HBr)
Molecular Weight (MW)	507.46
Formula	C28H30N2O2.HBr
CAS No.	133099-07-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 117 mg/mL (230.5 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: 2-[(3S)-1-[2-(2, 3-dihydro-1-benzofuran-5-yl)ethyl]pyrrolidin-3-yl]-2, 2-diphenylacetamide hydrobromide InChi Key: UQAVIASOPREUIT-VQIWEWKSSA-N InChi Code: InChI=1S/C28H30N2O2.BrH/c29-27(31)28(23-7-3-1-4-8-23, 24-9-5-2-6-10-24)25-14-17-30(20-25)16-13-21-11-12-26-22(19-21)15-18-32-26; /h1-12, 19, 25H, 13-18, 20H2, (H2, 29, 31); 1H/t25-; /m1./s1 SMILES Code: O=C(N)C(C1=CC=CC=C1)([CH]2CN(CCC3=CC4=C(OCC4)C=C3)CC2)C5=CC=CC=C5.[H]Br
Synonyms	UK-88525; Darifenacin; Emselex; Enablex. UK 88525; UK88525; Darifenacin HBr

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Amount: 10 mg

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