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Fexofenadine HCl

Fexofenadine HCl

Item no.	V1217-50mg
Manufacturer	InvivoChem LLC
CASRN	153439-40-8
Amount	50 mg
Quantity options	100 mg 1 g 250 mg 2 g 500 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	153439-40-8
Available
Description	InvivoChem Cat #:V1217CAS #:153439-40-8 Purity >=98% Description: Fexofenadine HCl (formerly MDL-16455A; Allegra; Terfenidine carboxylate; Telfast) is a potent histamine H1 receptor antagonist (antihistamine agent) used in the treatment of allergy symptoms such as hay fever, nasal congestion, and urticaria. Fexofenadine is a second-generation antihistamine as it is less able to pass the blood-brain barrier and cause sedation, compared tothe first-generation antihistamines.Fexofenadine exhibits a potent and concentration-dependent anti-anaphylactic activity with an IC50 value of 95.5nM. Fexofenadine shows only a weak competitive antagonist behaviour for the 5-HT2A receptorsfrom rat caudal artery with pA2 of 5.2. The IC50 of verapamil is 8.44 mM on the P-gp-mediated secretion of Fexofenadine. Description: References: Drugs R D. 2005; 6(6):371-84; J Pharm Sci. 2005 Feb; 94(2):233-9. References: Related CAS#: 83799-24-0 (free base); 548783-71-7 (Fexofenadine D6) 53439-40-8 (HCl) 479035-75-1 (meta-Fexofenadine, meta-MDL-16455)
Molecular Weight (MW)	538.12
Formula	C32H39NO4.HCl
CAS No.	153439-40-8 (HCl);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 107 mg/mL (198.8 mM)
	Water: 2 mg/mL (3.7 mM)
	Ethanol: 107 mg/mL (198.8 mM)
Other info	Chemical Name: 2-(4-(1-hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride InChi Key: RRJFVPUCXDGFJB-UHFFFAOYSA-N InChi Code: InChI=1S/C32H39NO4.ClH/c1-31(2, 30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37, 26-10-5-3-6-11-26)27-12-7-4-8-13-27; /h3-8, 10-13, 15-18, 28-29, 34, 37H, 9, 14, 19-23H2, 1-2H3, (H, 35, 36); 1H SMILES Code: O=C(O)C(C)(C)C1=CC=C(C(O)CCCN2CCC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)CC2)C=C1.[H]Cl
Synonyms	MDL 16455A; Allegra; Terfenidine carboxylate hydrochloride; Fexofenadine HCl; MDL-16-455A; MDL16455A; MDL 16 455A; Telfast

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Amount: 50 mg

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