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ticagrelor

ticagrelor

Item no.	V1303-250mg
Manufacturer	InvivoChem LLC
CASRN	274693-27-5
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1303CAS #:274693-27-5Purity >=98% Description: Ticagrelor (formerly AZD-6140; AR-C 126532XX; AZD6140; AR-C126532XX; Trade name: Brilinta; Brilique; Possia) is the first reversibly binding, potent and orally bioactive P2Y12 receptor antagonist used as an antiplatelet and anticoagulant. It inhibits P2Y12 receptor with a Ki of 2 NM. Ticagrelor was approved in 2011 by FDA as an antiplatelet drug for the prevention of stroke, heart attack and other events inpeople with acute coronary syndrome, meaning problems with blood supplyin the coronary arteries. Like the thienopyridines prasugrel, clopidogrel and ticlopidine, ticagrelor blocks adenosine diphosphate (ADP) receptors of subtype P2Y12. In contrast to the other antiplatelet drugs, ticagrelor has a binding site different from ADP, making it an allosteric antagonist, and the blockage is reversible. Description: References: J Thromb Haemost. 2009 Sep; 7(9):1556-65; Eur J Clin Pharmacol. 2010 May; 66(5):487-96. References: Related CAS#:1251765-07-7 (Ticagrelor metabolite M5)
Molecular Weight (MW)	522.57
Formula	C23H28F2N6O4S
CAS No.	274693-27-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 105 mg/mL (200.9 mM)
	Water:< 1 mg/mL
	Ethanol: 53 mg/mL (101.4 mM)
Other info	Chemical Name: (1S, 2S, 3R, 5S)-3-[7-[(1R, 2S)-2-(3, 4-Difluorophenyl)cyclopropylamino]-5-(propylthio)- 3H-[1, 2, 3]triazolo[4, 5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1, 2-diol InChi Key: OEKWJQXRCDYSHL-FNOIDJSQSA-N InChi Code: InChI=1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4, 8, 12, 15-17, 19-20, 32-34H, 2, 5-7, 9-10H2, 1H3, (H, 26, 27, 28)/t12-, 15+, 16+, 17-, 19-, 20+/m0/s1 SMILES Code: O[CH]1[CH](O)[CH](N2N=NC3=C(N[CH]4[CH](C5=CC=C(F)C(F)=C5)C4)N=C(SCCC)N=C32)C[CH]1OCCO
Synonyms	AZD 6140; AZD 6140; AR-C 126532XX; AR-C-126532XX; AZD-6140; AZD6140; AR-C126532XX; Ticagrelor; brand name: Brilinta; Brilique; Possia

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Amount: 250mg

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Delivery expected until 9/4/2025

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