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Almorexant HCl (ACT 078573)

Almorexant HCl (ACT 078573)

Item no.	V1308-2mg
Manufacturer	InvivoChem LLC
CASRN	913358-93-7
Amount	2 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	913358-93-7
Available
Description	InvivoChem Cat #:V1308CAS #:913358-93-7 Purity >=98% Description: Almorexant HCl (also known as ACT-078573; ACT078573), the hydrochloride salt of Almorexant, is a novel, potent, orally bioactive, competitive and dual orexin1/2 receptor antagonist indicated for the treatment of sleep disorders/insomnia. It inhibits OX1 and OX2 receptors with IC50s of 6.6 nM and 3.4 nM, respectively. In the inositol phosphates assay, almorexant acts as a competitive antagonist of hOX1R but a noncompetitive-like antagonist of hOX2R. Furthermore, almorexant shows effects on sleep in multiple species, including man. It reduces the time spent awake and increased the time spent in NREM and REM sleep dose-dependently in normal C57BL/6 mice. . Description: References: Nat Med. 2007; 13(2):150-5; Neuropsychopharmacology. 2012; 37(10):2210-21; Front Neurosci. 2014; 8:33. References: Related CAS#: 871224-64-5 (free base); 913358-93-7(HCl)
Molecular Weight (MW)	549.02
Formula	C29H32ClF3N2O3
CAS No.	913358-93-7 (HCl salt);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 72 mg/mL (131.1 mM)
	Water: < 1 mg/mL
	Ethanol: 51 mg/mL (92.9 mM)
Solubility (In vivo)	2% DMSO+25% beta-cyclodextrin+saline: 9 mg/mL
Synonyms	ACT078573 HCl; ACT-078573 HCl; Almorexant HCl; ACT 078573 HCl;

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Amount: 2 mg

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