cisplatin

Description: Cisplatin (CDDP; cis-Diaminodichloroplatinum; Trade names: Platinol; PlatinolAQ among others), an inorganic platinum complex acting as a DNA intercalating agent, is a widely used and classic chemotherapeutic drug and a potent inducer of growth arrest and apoptosis in a variety of cell types. It has been extensively used as a monotherapy or a component in combination therapy for treating a wide variety of cancers including testicular cancer, ovarian cancer, cervical cancer, breast cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. Upon IV (intravenous) administration, Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. This inhibits DNA synthesis and results in apoptosis and cell growth inhibition.

References: Oncogene. 2003 Oct 20; 22(47):7265-79; Int J Cancer. 1992 Apr 22; 51(1):108-15.

Trade names (US): Platinol; PlatinolAQ.

Trade names (other countries): Abiplatin; Blastolem; Briplatin; Cisplatyl; Citoplatino; Citosin; Lederplatin; Metaplatin; Neoplatin; Placis; Platamine; Platiblastin; PlatiblastinS; Platinex; Platinol AQ; PlatinolAQ VHA Plus; Platiran; Platistin; Platosin.

Chemical Name: (SP-4-2)-diamminedichloroplatinum; platinum, diaminedichloro-, cis-