p22077

Item no.	V1328-500mg
Manufacturer	InvivoChem LLC
CASRN	1247819-59-5
Amount	500mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1328CAS #:1247819-59-5Purity >=98% Description: P22077 (P-22077; P 22077) is a potent, cell-permeable and selective inhibitor of ubiquitin-specific protease USP7 (ubiquitin-specific protease 7) with potential antitumor activity. It inhibits USP7 with an EC50 of 8.6 uM, and also inhibits the closely related USP47. P22077 potently induces apoptosis in NB cells with an intact USP7-HDM2-p53 axis but not in NB cells with mutant p53 or without human homolog of MDM2 (HDM2) expression. P22077 also significantly augmented the cytotoxic effects of doxorubicin (Dox) and etoposide (VP-16) in NB cells with an intact USP7-HDM2-p53 axis. Moreover, P22077 was found to be able to sensitize chemoresistant LA-N-6 NB cells to chemotherapy. Description: References: Assay Drug Dev Technol. 2011 Apr; 9(2):165-73; Chem Biol. 2011 Nov 23; 18(11):1401-12. References:
Molecular Weight (MW)	315.32
Formula	C12H7F2NO3S2
CAS No.	1247819-59-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 63 mg/mL (199.8 mM)
	Water:< 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: 1-(5-((2, 4-difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone InChi Key: RMAMGGNACJHXHO-UHFFFAOYSA-N InChi Code: InChI=1S/C12H7F2NO3S2/c1-6(16)11-5-9(15(17)18)12(20-11)19-10-3-2-7(13)4-8(10)14/h2-5H, 1H3 SMILES Code: CC(C1=CC([N+]([O-])=O)=C(SC2=CC=C(F)C=C2F)S1)=O
Synonyms	P22077; P-22077; P 22077

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