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Description: DMH1 (DMH-1; DMH 1) is a selective and 2nd-generation small molecule inhibitor of BMP (bone morphogenetic protein) receptor inhibitor with potential antitumor activity. It inhibits ALK2 with an IC50 of 107.9 nM and exhibits no effects against other kinases such as AMPK, ALK5, KDR (VEGFR-2) or PDGFR.
References: ACS Chem Biol. 2010 Feb 19; 5(2):245-53; ACS Chem Biol. 2011 Sep 16; 6(9):952-61.
SMILES Code: CC(OC1=CC=C(C2=CN3C(N=C2)=C(C4=CC=NC5=CC=CC=C45)C=N3)C=C1)C
Exact Mass: 380.16371
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