doxorubicin-hcl

Description: Doxorubicin HCl (formerly known as Adriamycin; FI 106; Adriblastina; DOXOCELL; Doxolem; NSC-123127 etc.) is an anthracycline antibiotic agent with anticancer activity. It inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells. It was approved for use as an antineoplastic agent. Doxorubicin is isolated from the bacterium Streptomyces peucetius var. caesius, and is the hydroxylated congener of daunorubicin. Doxorubicin acts by intercalating between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II.

References: Cancer Res. 2009 May 15; 69(10):4294-300; Food Chem Toxicol. 2010 Jun; 48(6):1425-38.

Related CAS#: 23214-92-8 (free base); 23214-92-8 (Doxorubicin free base); 480998-12-7 (MC-DOXHZN hydrochloride is an albumin-binding prodrug of Doxorubicin, with acid-sensitive properties); 151038-96-9 (MC-DOXHZN); 108852-90-0 Nemorubicin, Methoxymorpholinyldoxorubicin; PNU 152243; PNU-152243A; 56390-09-1 Epirubicin hydrochloride, 4'-Epidoxorubicin hydrochloride; 56420-45-2 (Epirubicin); 1361644-26-9 (Aldoxorubicin; INNO-206; DOXO-EMCH);