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irinotecan-hcl-trihydrate

irinotecan-hcl-trihydrate

Item no.	V1410-5g
Manufacturer	InvivoChem LLC
CASRN	136572-09-3
Amount	5g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1410CAS #:136572-09-3 Purity >=98% Description: Irinotecan HCl trihydrate (formerly CPT-11; CPT 11; Irinophore C; Irinotecan lactone; Irinotecanum ), the hydrochloride salt and trihydrated form of irinotecan which is an antitumor drug and a soluble prodrug of SN-38, is a semisynthetic derivative of camptothecin approved for cancer treatment. It inhibits the proliferation of P388 leukemia with an IC50 value of 3.4uM. Irinotecan was developed to avoid toxicity and to improve therapeutic efficacy of camptothecin. Description: References: Cancer Chemother Pharmacol. 2002 Apr; 49(4):329-35; Int J Cancer. 1997 Jan 27; 70(3):335-40. References: Related CAS#: 100286-90-6 (HCl); 97682-44-5 (Free base); 136572-09-3 (HCl trihydrate) 136572-09-3 (HCl trihydrate)
Molecular Weight (MW)	677.18
Formula	C33H38N4O6.HCl.3H2O
CAS No.	136572-09-3 (HCl trihydrate);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (147.7 mM)
	Water: < 1 mg/mL
	Ethanol: 7 mg/mL (10.3 mM)
Solubility (In vivo)	30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
Synonyms	CPT-11 HCl Trihydrate; CPT11; (+)-Irinotecan; Camptosar; CPT-11; CPT 11; Irinophore C; Irinotecan; Irinotecan lactone; Irinotecanum

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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