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Description: Vidarabine (Ara-A; Adenine Arabinoside; 9-beta-D-Arabinofuranosyladenine; Arabinofuranosyladenine) is an approved antiviral drug that interfers with the synthesis of viral DNA, and is mainly used to treat HSV and VZV: herpes simplex and varicella zoster viruses. Vidarabine and Acyclovir have a synergistic effect on wild type. Vidarabine is capable of inhibiting acyclovir-resistant/TK-deficient mutants of HSV and VZV, because it is phosphorylated to its active vidarabine–triphosphate form by cellular kinases and is not dependent for its activation on the viral TK.
References: Antiviral Res. 2006 Nov; 72(2):157-61; Antivir Chem Chemother. 2004 Sep; 15(5):281-5.
Related CAS#: 29984-33-6 (phosphate); 53910-25-1 (Pentostatin); 5536-17-4 (free base); 24356-66-9 (hydrate)
Chemical Name: (2R, 3S, 4S, 5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3, 4-diol
InChi Key: OIRDTQYFTABQOQ-UHTZMRCNSA-N
InChi Code: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4, 6-7, 10, 16-18H, 1H2, (H2, 11, 12, 13)/t4-, 6-, 7+, 10-/m1/s1
SMILES Code: O[CH]1[CH](N2C=NC3=C(N)N=CN=C23)O[CH](CO)[CH]1O
Adenine Arabinoside; 9-beta-D-Arabinofuranosyladenine; Vira A; Vira-A; ViraA; Ara-A; Ara A; Arabinofuranosyladenine; 9-beta-Arabinofuranosyladenine; Vidarabine.
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