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baf312-siponimod

baf312-siponimod

Item no.	V1505-1g
Manufacturer	InvivoChem LLC
CASRN	1230487-00-9
Amount	1g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1505CAS #:1230487-00-9Purity >=98% Description: Siponimod (BAF 312) is a novel, potent and orally bioavailable S1P receptor modulator, with selectivity for S1P1 and S1P5 receptors (EC50 of 0.39 nM and 0.98 nM) and with the potential for treating medical conditions characterized by significant immunopathology. It exhibits > 1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. In vitro metabolism studies with liver microsomes have shown that the metabolic clearance of BAF312 is high in rat, low to moderate in monkey and human being, and low in dog and mouse. Description: References: Br J Pharmacol. 2012 Nov; 167(5):1035-47; J Immunol. 2013 Apr 1; 190(7):3533-40. References: Related CAS #: 1234627-85-0 (fumarate) 1230487-00-9 (free base)
Molecular Weight (MW)	516.6
Formula	C29H35F3N2O3
CAS No.	1230487-00-9
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (193.6 mM)
	Water: < 1 mg/mL
	Ethanol: 44 mg/mL (85.2 mM)
Other info	Chemical Name: (E)-1-(4-(1-(((4-cyclohexyl-3-(trifluoromethyl)benzyl)oxy)imino)ethyl)-2-ethylbenzyl)azetidine-3-carboxylic acid InChi Key: KIHYPELVXPAIDH-HNSNBQBZSA-N InChi Code: InChI=1S/C29H35F3N2O3/c1-3-21-14-23(10-11-24(21)15-34-16-25(17-34)28(35)36)19(2)33-37-18-20-9-12-26(22-7-5-4-6-8-22)27(13-20)29(30, 31)32/h9-14, 22, 25H, 3-8, 15-18H2, 1-2H3, (H, 35, 36)/b33-19+ SMILES Code: CCC1=C(CN2CC(C(O)=O)C2)C=CC(/C(C)=N/OCC3=CC(C(F)(F)F)=C(C4CCCCC4)C=C3)=C1
Synonyms	BAF-312; BAF 312; BAF312; WHO 9491; WHO-9491; WHO9491; NVP-BAF-312; NVP-BAF 312; NVP-BAF312; NVP-BAF312-AEA; NVP-BAF312-NX; Siponimod; Mayzent.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1g

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Delivery expected until 9/4/2025

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