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Description: SR 59230A HCl is a potent, brain penetrant and selective beta3 adrenoceptor antagonist with IC50 values of 40, 408 and 648 nM for beta3, beta1 and beta2 receptors respectively. SR-59230A was shown to block the hyperthermia produced by MDMA inanimal studies. SR 59230A blocks MDMA-induced hyperthermia, while athigh concentrations it blocks hyperthermia but also increases heat lossthrough an alpha1-AR antagonistic mechanism.
References: Mol Pharmacol. 1996 Jan; 49(1):7-14.; Diabetes Obes Metab. 2012 Oct; 14(10):960-2.
Related CAS: 1135278-41-9 (HCl) 174689-39-5 (free base); 174689-39-5 (oxalate)
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