10058-f4

Description: 10058-F4 is a novel potent and selective c-Myc inhibitor that specifically inhibits the c-Myc-Max protein protein interaction and prevents the transactivation of c-Myc target gene expression. 10058-F4 markedly increases valproic acid-induced cell death in Jurkat and CCRF-CEM T-lymphoblastic leukemia cells. 10058-F4 inhibits proliferation, downregulates human telomerase reverse transcriptase and enhances chemosensitivity in human hepatocellular carcinoma cells. 10058-F4 induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia.

References: Exp Hematol. 2006 Nov; 34(11):1480-9; Cancer Chemother Pharmacol. 2009 Mar; 63(4):615-25.