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pf-3758309

pf-3758309

Item no.	V1594-5mg
Manufacturer	InvivoChem LLC
CASRN	898044-15-0
Amount	5 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	898044-15-0
Available
Description	InvivoChem Cat #:V1594CAS #:898044-15-0Purity >=98% Description: PF-03758309, a pyrrolopyrazole analog, is a novel, potent, orally bioavailable, and ATP-competitive small molecule inhibitor of PAK4 (p21-activated kinase 4) with IC50 of 1.3 NM. As an inhibitor of PAK4, PF-3758309 has potential antineoplastic activity. PF-03758309 binds to PAK4 and inhibits PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival. References: Proc Natl Acad Sci U S A. 2010 May 18; 107(20):9446-51.
Molecular Weight (MW)	490.62
Formula	C25H30N8OS
CAS No.	898044-15-0
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 98 mg/mL (199.7 mM)
	Water: < 1 mg/mL
	Ethanol: 98 mg/mL (199.7 mM)
Other info	Chemical Name: (S)-N-(2-(dimethylamino)-1-phenylethyl)-6, 6-dimethyl-3-((2-methylthieno[3, 2-d]pyrimidin-4-yl)amino)-4, 6-dihydropyrrolo[3, 4-c]pyrazole-5(1H)-carboxamide. InChi Key: AYCPARAPKDAOEN-LJQANCHMSA-N InChi Code: InChI=1S/C25H30N8OS/c1-15-26-18-11-12-35-20(18)23(27-15)29-22-17-13-33(25(2, 3)21(17)30-31-22)24(34)28-19(14-32(4)5)16-9-7-6-8-10-16/h6-12, 19H, 13-14H2, 1-5H3, (H, 28, 34)(H2, 26, 27, 29, 30, 31)/t19-/m1/s1 SMILES Code: O=C(N(C1)C(C)(C)C2=C1C(NC3=C4C(C=CS4)=NC(C)=N3)=NN2)N[CH](C5=CC=CC=C5)CN(C)C
Synonyms	PF-03758309; PF03758309; PF 03758309; PF-3758309; PF-3758309; PF3758309; PF 3758309.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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