ck-636

Item no.	V1616-5mg
Manufacturer	InvivoChem LLC
CASRN	442632-72-6
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	442632-72-6
Available
Description	InvivoChem Cat #:V1616CAS #:442632-72-6Purity >=98% Description: CK-636 (also called CK-0944636) is a potent inhibitor of the actin-related protein Arp2/3 complex with IC50 of 4 uM, 24 uM and 32 uM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively. CK-636 binds between Arp2 and Arp3 where it appears to block movement of Arp2 and Arp3 into their active conformation and inhibits Arp2/3 complex’s ability to nucleate actin filaments. In a concentration dependence way, CK-636 reduced the formation of actin filament comet tails by Listeria with IC50 value of 22 uM in infected SKOV3 cells. References: Nature. 2009 Aug 20; 460(7258):1031-4; PLoS One. 2013 Sep 12; 8(9):e73960.
Molecular Weight (MW)	284.38
Formula	C16H16N2OS
CAS No.	442632-72-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 57 mg/mL (200.4 mM)
	Water: < 1 mg/mL
	Ethanol: 50 mg/mL (175.8 mM)
Other info	Chemical Name: N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide InChi Key: ACAKNPKRLPMONU-UHFFFAOYSA-N InChi Code: InChI=1S/C16H16N2OS/c1-11-12(13-5-2-3-6-14(13)18-11)8-9-17-16(19)15-7-4-10-20-15/h2-7, 10, 18H, 8-9H2, 1H3, (H, 17, 19) SMILES Code: O=C(C1=CC=CS1)NCCC2=C(C)NC3=C2C=CC=C3
Synonyms	CK0944636; CK-0944636; CK 0944636; CK636; CK 636; CK-636

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