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Amiloride HCl dihydrate (MK 870)

Amiloride HCl dihydrate (MK 870)

Item no.	V1652-100mg
Manufacturer	InvivoChem LLC
CASRN	17440-83-4
Amount	100 mg
Quantity options	1 g 250 mg 25 g 500 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	17440-83-4
Available
Description	InvivoChem Cat #:V1652CAS #:17440-83-4 Purity >=98% Description: Amiloride HCl dihydrate (MK 870) is a potent and selective epithelial sodium channel (ENaC) blocker used in the management of hypertension and congestive heart failure. Amiloride was first approved in 1967 in the management of hypertension and congestive heart failure. Amiloride works by directly blocking the epithelial sodium channel (ENaC) thereby inhibiting sodium reabsorption in the late distal convoluted tubules, connecting tubules, and collecting ducts in the kidneys (this mechanism is the same for triamterene). This promotes the loss of sodium and water from the body, but without depleting potassium. References: Oncogene. 2005 Jan 13; 24(3):355-66; J Cell Biol. 2010 Feb 22; 188(4):547-63. Related CAS#: 2016-88-8 (Amiloride HCl); 2609-46-3 (free)
Molecular Weight (MW)	302.12
Formula	C6H8ClN7O.HCl.2H2O
CAS No.	17440-83-4 (Amiloride HCl dihydrate)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 60 mg/mL (198.6 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Chemical Name	3, 5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride hydrate
Synonyms	MK870; MK-870; MK 870; Amiloride Hydrochloride; Midamor; Midoride; Modamide.

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Amount: 100 mg

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