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Description: O4I1 is a novel and potent inducer of Oct3/4 and can enhance Oct3/4 expression. Oct3/4 is specifically expressed in the ES cells, epiblast, preimplantation embryos, and germ cells, et al. O4I1 not only promoted expression and stabilization of Oct3/4 but also enhanced its transcriptional activity in diverse human somatic cells, implying the possible benefit from using this class of compounds in regenerative medicine.
References: J Med Chem. 2015 Jun 25; 58(12):4976-83.
Chemical Name: 4-[(4-Methoxyphenyl)methoxy]benzeneacetonitrile
InChi Key: QJEJLARVLKHYFW-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H15NO2/c1-18-15-6-4-14(5-7-15)12-19-16-8-2-13(3-9-16)10-11-17/h2-9H, 10, 12H2, 1H3
SMILES Code: N#CCC1=CC=C(OCC2=CC=C(OC)C=C2)C=C1
O4I1; O4I-1; O4I 1
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