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tak-875

tak-875

Item no.	V1803-5mg
Manufacturer	InvivoChem LLC
CASRN	1000413-72-8
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1000413-72-8
Available
Description	InvivoChem Cat #:V1803CAS #:1000413-72-8 Purity >=98% Description: Fasiglifam (also known as TAK-875) is a novel, long-acting, selective and orally bioavailable and selective GPR40 agonist with EC50 of 14 nM in human GPR40 expressing CHO cell line, it is 400-fold more potent than oleic acid. TAK-875 has a favorable pharmacokinetic profile which enables long-acting drug efficacy. TAK-875 exhibited potent agonistic activity and high binding affinity to the human GPR40 receptor. In addition, TAK-875 showed excellent agonist potency and selectivity for GPR40 receptor over other members of the FFA receptor family (e.g. EC50> 10 uM for others). References: ACS Med Chem Lett. 2010 Jun 18; 1(6):290-4; J Pharmacol Exp Ther. 2011 Oct; 339(1):228-37. Related CAS#: 1374598-80-7 (hydrate)
Molecular Weight (MW)	533.63
Formula	C29H32O7S.1/2H2O
CAS No.	1000413-72-8 (free);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (187.4 mM)
	Water: < 1 mg/mL
	Ethanol:< 1 mg/mL
Solubility (In vivo)	0.5% CMC+0.25% Tween 80: 30 mg/mL
Synonyms	Fasiglifam; TAK875; TAK-875; TAK 875

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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