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pitavastatin-calcium

pitavastatin-calcium

Item no.	V1859-250mg
Manufacturer	InvivoChem LLC
CASRN	147526-32-7
Amount	250mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	147526-32-7
Available
Description	InvivoChem Cat #:V1859CAS #:147526-32-7Purity >=98% Description: Pitavastatin calcium (also called NK-104 Calcium) is a novel and potent drug of the statin class. Pitavastatin Calcium acts as a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase), resulting in a reduction in LDL cholesterol synthesis. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting NADPH oxidase. In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187. Furthermore, pitavastatin inhibits the up-regulation of conductance calcium-activated potassium channels by lowering cholesterol levels in cells. References: Cardiol Rev. 2010 Sep-Oct; 18(5):264-7; J Clin Invest. 2001 Jun; 107(11):1423-32. Related CAS #: 147526-32-7 (calcium); 586966-54-3 (tert-Buthyl Pitavastatin); 147511-69-1 (free acid); 141750-63-2 (lactone); 1159588-21-2 (Z)-Pitavastatin cacium; 254452-92-1 (3S, 5S)-Pitavastatin cacium; 254452-88-5 (3S, 5R)-Pitavastatin cacium; 2070009-71-9 (Pitavastatin D4); 141750-63-2 (Pitavastatin lactone);
Molecular Weight (MW)	880.98
Formula	C50H46CaF2N2O8
CAS No.	147526-32-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 51 mg/mL (57.9 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Other info	Chemical Name: calcium (E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3, 5-dihydroxyhept-6-enoate InChi Key: RHGYHLPFVJEAOC-WUVPNHNWSA-L InChi Code: InChI=1S/2C25H24FNO4.Ca/c226-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31; /h21-4, 7-12, 16, 18-19, 28-29H, 5-6, 13-14H2, (H, 30, 31); /q; ; +2/p-2/b2*12-11+; SMILES Code: C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.[Ca+2]
Synonyms	NK-104 Calcium; Livalo; NK104; Pitavastatin hemicalcium; Nisvastatin; NK 104; NK-104; P 872441; P-872441

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Amount: 250mg

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Delivery expected until 7/3/2025

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