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salinomycin

salinomycin

Item no.	V1861-25mg
Manufacturer	InvivoChem LLC
CASRN	53003-10-4
Amount	25mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V1861CAS #:53003-10-4Purity >=98% Description: Salinomycin (also known as AHR-3096, or Procoxacin) is a potent antibacterial and coccidiostat ionophore therapeutic agent with potential anticancer activities by targeting stem cells. Salinomycin (Procoxacin) has been shown by Piyush Gupta to kill breast cancer stem cells at least 100 times more effectively than another popular anti-cancer compound (paclitaxel) in mice. The mechanism of action by which salinomycin (Procoxacin) kills cancer stem cells specifically remains unknown, but is thought to be due to its action as a potassium ionophore due to the detection of Nigericin in the same compound screen. Salinomycin has high toxicity and a narrow therapeutic window which may limit its clinical use. References: J Antibiot (Tokyo). 1974 Nov; 27(11):814-21; Chem Biol Drug Des. 2012 Mar; 79(3):235-8. Related CAS#: 55721-31-8 (Salinomycin sodium); 53003-10-4 (free acid)
Molecular Weight (MW)	751.00
Formula	C42H70O11
CAS No.	53003-10-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: < 1 mg/mL
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
SMILES	[H][C]1([C](C)(CC2)O[C]32[CH](O)C=C[C]4(O[C]([H])([CH](CC)C([CH](C)[CH](O)[CH](C)[C]5([H])O[C]([CH](CC)C(O)=O)([H])CC[CH]5C)=O)[CH](C)C[CH]4C)O3)CC [C](CC)(O)[CH](C)O1
Synonyms	Procoxacin; BioCox; Sacox; SalocinAHR-3096; AHR 3096; AHR3096; HSDB 7032; HSDB7032; HSDB-7032; K 364; Salinomycin; Coxistac.

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Amount: 25mg

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