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Description: Cyproheptadine HCl hydrate is a hydrochloride salt form of cyproheptadine which is a histamine receptor antagonist. In addition, Cyproheptadine is also a serotonin as well as an antimuscarinic reagent. It is used to treat for postgastrectomy-dumping syndrome, pruritic dermatoses, migraine, anorexia, and pituitary-dependent Cushing's syndrome. As a 5-HT2A receptor antagonist, cyproheptadine is found to reverse serotonin-enhanced ADP-induced platelet aggregation in vitro and ex vivo suggesting its antiplatelet and thromboprotective effects.
References: J Anal Toxicol. 1998 Jan-Feb; 22(1):72-4; PLoS One. 2014 Jan 23; 9(1):e87026.
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