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ascomycin-fk520

ascomycin-fk520

Item no.	V1936-25mg
Manufacturer	InvivoChem LLC
CASRN	104987-12-4
Amount	25 mg
Quantity options	100 mg 1 g 250 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	104987-12-4
Available
Description	InvivoChem Cat #:V1936CAS #:104987-12-4Purity >=98% Description: Ascomycin (also known as FK520, FR 900520, Immunomycin), a natural product isolated from Streptomyces, is an ethyl analog of tacrolimus (FK506) and a neutral macrolide immunosuppressant, which prevents rejection after an organ transplant. Ascomycin suppresses immune response in vitro with IC50 of 0.55 nM for mouse mixed lymphocyte. Ascomycin inhibits calcineurin phosphatase with IC50 of 49 nM through formation of an FKBP12-FK520-calcineurin ternary complex. References: J Antibiot (Tokyo). 1988 Nov; 41(11):1592-601; J Pharmacol Exp Ther. 2002 Sep; 302(3):1278-85. Related CAS #: 104987-11-3 (tacrolimus free base); 109581-93-3 (tacrolimus hydrate); 11011-38-4 (Ascomycin)
Molecular Weight (MW)	792.01
Formula	C43H69NO12
CAS No.	104987-12-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (126.3 mM)
	Water: < 1 mg/mL
	Ethanol: 100 mg/mL (126.3 mM)
Solubility (In vivo)	O=C([C](CCCC1)([H])N1C(C([C]2(O)[CH](C)C[CH](OC)[C](O2)([H])[CH](OC)C[CH](C)C/C(C)=C/[CH]3CC)=O)=O)O[CH](/C(C)=C/[CH]4C[CH](OC)[CH](O)CC4)[CH](C)[CH](O)CC3=O
Synonyms	FR 900520, FK-520; FK-520; FK-520; FR900520; FR-900520; FR-900520; L 683590; L-683590; L683590; Changchuanmycin; Immunomycin

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25 mg

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