Bindarit (AF2838)

Description: Bindarit (also known as AF 2838) is a potent and selective inhibitor of monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8. Bindarit treatment causes a dose-dependent inhibition of the capacity of human monocytes to produce monocyte chemotactic protein-1 (MCP-1) in response to bacterial LPS or C. albicans with IC50 of 172 uM and 403 uM, respectively. The inhibition of LP-induced MCP-1 production by Bindarit is associated with reduced levels of MCP-1 mRNA transcripts with IC50 of 75 uM. Bindarit inhibits the production of MCP-1 by LPS-stimulated MM6 cells with IC50 of 425 uM, without affecting the release of IL-8 or IL-6.

References: Kidney Int. 1998 Mar; 53(3):726-34; Eur Cytokine Netw. 1999 Sep; 10(3):437-42; J Invest Dermatol. 2007 Aug; 127(8):2031-41.