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Rupatadine

Rupatadine

Item no.	V2041-100mg
Manufacturer	InvivoChem LLC
CASRN	158876-82-5
Amount	100 mg
Quantity options	10 g 1 g 250 mg 2 g 500 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	158876-82-5
Available
Description	InvivoChem Cat #:V2041CAS #:158876-82-5Purity >=98% Description: Rupatadine (also known as UR-12592) is a potent inhibitor of PAFR and histamine (H1) receptor with Ki of 550 nM and 102 nM, respectively. Rupatadine inhibits both platelet-activating factor (PAF) and histamine (H1) effects through its interaction with specific receptors. Rupatadine competitively inhibits histamine-induced guinea pig ileum contraction (pA2 = 9.29 +/- 0.06) without affecting contraction induced by ACh, serotonin or leukotriene D4(LTD4). It also competitively inhibits PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2= 6.68 +/- 0.08) and in human platelet-rich plasma (HPRP) (IC50 = 0.68 uM), while not affecting ADP- or arachidonic acid-induced platelet aggregation. Description: References: J Pharmacol Exp Ther. 1997 Jan; 280(1):114-21. References: Related CAS#: 158876-82-5 (free base); 182349-12-8 (Fumarate) : 158876-82-5 (free base); 182349-12-8 (Fumarate)
Molecular Weight (MW)	415.96
Formula	C26H26ClN3
CAS No.	158876-82-5
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 9 mg/mL (16.9 mM)
	Water: < 1 mg/mL
	Ethanol: 13 mg/mL (24.4 mM)
Solubility (In vivo)	30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
Synonyms	Rupatadine; UR-12592; UR 12592; UR12592; Pafinur; Rupax; Rupafin; Alergoliber; Rinialer; Ralif

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Amount: 100 mg

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