eln441958

Description: ELN441958 is a novel, potent, and neutral bradykinin B1 Receptor antagonist which inhibits the binding of the B1 agonist ligand 3HDAKD to IMR-90 cells with Ki of 0.26 nM.

References: Hawkinson JE, Szoke BG, Garofalo AW, Hom DS, Zhang H, Dreyer M, Fukuda JY, Chen L, Samant B, Simmonds S, Zeitz KP, Wadsworth A, Liao A, Chavez RA, Zmolek W, Ruslim L, Bova MP, Holcomb R, Butelman ER, Ko MC, Malmberg AB. Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958. J Pharmacol Exp Ther. 2007 Aug; 322(2):619-30. Epub 2007 Apr 30. PubMed PMID: 17470643.