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Description: MSX-122 is a novel, potent and orally bioavailable inhibitor/partial antagonist of CXCR4 which inhibits CXCR4/CXCL12 actions with an IC50 of 10 nM. It has potential anticancer and antiviral activities. MSX-122 acts by binding to CXCR4, thus preventing its interaction with stromal derived factor-1 (SDF-1), leading to decreased tumor cell proliferation and migration.
References: Development of a unique small molecule modulator of CXCR4. PLoS One. 2012; 7(4):e34038.; Inhibition of the CXCL12/CXCR4-Axis as Preventive Therapy for Radiation-Induced Pulmonary Fibrosis. PLoS One. 2013 Nov 7; 8(11):e79768. doi: 10.1371/journal.pone.0079768.
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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