Comparison

SR-717 lithium

Item no. V2205-5mg
Manufacturer InvivoChem LLC
CASRN 2375421-09-1
Amount 5 mg
Quantity options 100 mg 10 mg 1 mg 250 mg 25 mg 50 mg
Category
Type Biochemicals
Specific against other
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias 2375421-09-1
Available
Description
InvivoChem Cat #:V2205CAS #:2375421-09-1Purity >=98%

Description: SR-717 lithium is a novel, potent and non-nucleotide STING (stimulator of interferon genes) agonist with anticancer activities. It has EC50 values of 2.1 uM and 2.2 uM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 functions as a direct cyclic guanosine monophosphate-adenosinemonophosphate (cGAMP) mimetic that induces the same 'closed'conformation of STING. SR-717 displayed antitumor activity; promoted theactivation of CD8+ T, natural killer, and dendritic cells in relevanttissues; and facilitated antigen cross-priming. SR-717 also induced theexpression of clinically relevant targets, including programmed celldeath 1 ligand 1 (PD-L1), in a STING-dependent manner.

References: Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic. Science. 2020 Aug 21; 369(6506):993-999.

Related CAS #: 2375420-34-9 (free acid) 2375421-09-1 (lithium)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 5 mg
Available: In stock
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