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Description: Lorediplon is a nonbenzodiazepine of the pyrazolopyrimidine family that is being pursued as a treatment for insomnia but has not completed development. Lorediplon demonstrated a dose-dependent improvement in sleep, whereas zolpidem showed a more sustained WASO effect. No next-day hangover effects were observed. These sleep effects are also consistent with the pharmacokinetic profile of lorediplon. These results warrant clinical trials in patients with insomnia.
References: Zisapel N. Current Phase II investigational therapies for insomnia. ExpertOpin Investig Drugs. 2015 Mar; 24(3):401-11. doi: 10.1517/13543784.2015.987340.Epub 2014 Nov 25. Review. PubMed PMID: 25423562.
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