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cp-466722

cp-466722

Item no.	V2528-5mg
Manufacturer	InvivoChem LLC
CASRN	1080622-86-1
Amount	5mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1080622-86-1
Available
Description	InvivoChem Cat #:V2528CAS #:1080622-86-1Purity >=98% Description: CP-466722 is a novel, specific and reversible ATM inhibitor with an IC50 value of 4.1 uM, it does not affect ATR and inhibits PI3K or PIKK family members in cells. Inhibition of cellular ATM kinase activity was rapidly and completely reversed by removing CP466722. CP-466722 is regarded as a promising drug to increase tumor cells sensitivity to IR. When tested with Hela, MCF-7 and mouse cells pre-treated with IR which induced the increase in ATM-dependent phosphorylation events and then CP-466722 treatment resulted in the disruption of ATM-dependent phosphorylation events and inhibiton of ATM-dependent p53 inducetion at the minimal dose of 6 uM. Description: References: Cancer Res. 2008 Sep 15; 68(18):7466-74; J Biomol Screen. 2014 Apr; 19(4):538-46. References:
Molecular Weight (MW)	349.35
Formula	C17H15N7O2
CAS No.	1080622-86-1
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 0.28 mg/mL (0.8 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	Chemical Name: 1-(6, 7-dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1, 2, 4-triazol-5-amine InChi Key: ILBRKJBKDGCSCB-UHFFFAOYSA-N InChi Code: InChI=1S/C17H15N7O2/c1-25-13-7-10-12(8-14(13)26-2)20-9-21-16(10)24-17(18)22-15(23-24)11-5-3-4-6-19-11/h3-9H, 1-2H3, (H2, 18, 22, 23) SMILES Code: COC1=C(C=C2C(=C1)C(=NC=N2)N3C(=NC(=N3)C4=CC=CC=N4)N)OC
Synonyms	CP-466722; CP 466722; CP466722

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