740 Y-P (PDGFR 740Y-P)

Description: 740 Y-P is a cell-permeable peptide acting as a phosphopeptide activator of PI3K. 740 Y-P plays an important role in PI3K/AKT signaling pathway. When tested with human melanoma MNT-1 cells, 20 uM 740 Y-P for 24 hours treatment significantly reduced the number of M6PR-positive vacuoles induced by sucrose via activating PI3K. In cerebellar granule cells in the circumstance of serum deprivation, 740 Y-P treatments reduced the cell death rate via binding to p85 which was correlated with PI 3-kinase-dependent phosphorylation of Akt process.

References:Mol Cell Neurosci. 1999 Apr; 13(4):272-80; Biochem Biophys Res Commun. 1998 Oct 9; 251(1):148-52.